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A Phase 1 Trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion
BMC Clinical Pharmacology, 08/03/09

Harris DS et al. – No pharmacological interaction occurred between selegiline and a substantial dose of intravenous cocaine, suggesting the combination will be safe in pharmacotherapy trials. Selegiline produced few changes in subjective response to the cocaine challenge perhaps because of some psychoactive neurotransmitters changing in opposite directions.

Today in Drug Interactions...keeping you current

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Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
Pain, 12/16/09

Cyclosporine Versus Tacrolimus in Immunosuppressive Maintenance Regimens in Renal Transplants in Brazil: Survival Analysis from 2000 to 2004
Annals of Pharmacotherapy, 12/16/09

'Party pill' drugs - BZP and TFMPP
New Zealand Medical Journal, 12/14/09

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A Clinical Review of Echinocandins in Pediatric Patients
Annals of Pharmacotherapy, 12/16/09

Sanofi Pasteur expands study of vaccine against Clostridium difficile into the U.S.
Sanofi-aventis, 12/16/09

Second Pivotal Phase III Study of Gileads Darusentan for Resistant Hypertension Misses Primary Endpoints
Gilead, 12/15/09

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Today in Neuro/Psych pharmacology...keeping you current

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Eslicarbazepine: A novel antiepileptic agent designed for improved efficacy and safety
Formulary , 12/16/09

Phenylephrine but not Ephedrine Reduces Frontal Lobe Oxygenation Following Anesthesia-Induced Hypotension
Neurocritical Care , 12/16/09

Acetazolamide and midazolam act synergistically to inhibit neuropathic pain
Pain, 12/16/09

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