Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Statins and cancer risk
Your Article Summary
See Latest ArticlesBlinding of AMP-dependent kinase by methylglyoxal: A mechanism that allows perpetuation of hepatic insulin resistance
Medical Hypotheses, 08/13/09
Gugliucci A – The authors hypothesize that excess MG in the above–mentioned conditions blocks the sensing of AMP by AMPK, thereby favoring gluconeogenesis (thus hepatic glucose output and hyperglycemia) and lipogenesis (hepatic steatosis and high VLDL), hallmarks of insulin resistance and diabetes. The hypothesis may explain, for instance, the perpetuation of hepatic insulin resistance, as well as part of the action of metformin, which is a potent anti–glycation agent.
Related Articles
Insulin resistance in hyperthyroidism: the role of IL-6 and TNFalpha
European Journal of Endocrinology, 11/04/09
Relevance Score: 70%
Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals
Trends in Endocrinology and Metabolism, 11/03/09
Relevance Score: 70%
Evolution, body composition, insulin receptor competition, and insulin resistance
Preventive Medicine, 11/02/09
Relevance Score: 70%
Age-Associated Increase in Abdominal Obesity and Insulin Resistance, and Usefulness of AHA/NHLBI Definition of Metabolic Syndrome for Predicting Cardiovascular Disease in Japanese Elderly with Type 2 Diabetes Mellitus
Gerontology, 10/19/09
Relevance Score: 70%
Insulin Resistance, beta-Cell Dysfunction, and Conversion to Type 2 Diabetes in a Multiethnic Population: The Insulin Resistance Atherosclerosis Study (IRAS)
Diabetes Care, 10/14/09
Relevance Score: 70%
Today in Drug Resistance...keeping you current
Receive free subspecialty "5-minute updates" via email
Characterization of Baseline Methicillin-Resistant Staphylococcus aureus Isolates Recovered from Phase IV Clinical Trial for Linezolid
Journal of Clinical Microbiology, 12/03/09
Two antimalaria drugs are tolerated regimens in regions with resistance
Formulary , 12/02/09
Imipenem Resistance in Pseudomonas aeruginosa: Emergence, Epidemiology, and Impact on Clinical and Economic Outcomes
Infection Control and Hospital Epidemiology, 12/02/09
Sponsor
Article Search
Sponsor