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See Latest ArticlesValproic Acid-induced Agranulocytosis
International Journal of Gerontology, 08/05/09
Hsu H–C et al. – Valproic acid is considered to be the most well–tolerated antiepileptic drug. However, few cases of neutropenia or leukopenia caused by valproic acid have been reported. The authors present a patient who took valproic acid to treat a complication of brain surgery and in whom severe agranulocytosis occurred after 2.5 months. Valproic acid was stopped immediately, and granulocyte colony–stimulating factor was administered for 2 days. The patient's white blood cell count returned to normal within 2 weeks. The result of bone marrow aspiration was compatible with drug–induced agranulocytosis. This case illustrates that patients who take valproic acid may need regular checking of complete blood cell count.
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