Pharmacy Medical News about Lansoprazole

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Pharmacokinetic properties of lansoprazole (30-mg enteric-coated capsules) and its metabolites: A single-dose, open-label study in healthy Chinese male subjects
Current Therapeutic Research, 07/31/09

Song M et al. – The plasma t½z did not appear to reflect the duration of suppression of gastric acid secretion: the t½z values of lansoprazole and the 2 metabolites were ~2 to 2.5 hours, while the acid–inhibitory effect lasted >24 hours. Cmax, AUC, and t½z of lansoprazole, and especially lansoprazole sulfone, varied. Differences in metabolism types and/or genotype of CYP2C19 should be taken into account when planning a lansoprazole dosing regimen.

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Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction
World Journal of Gastroenterology, 10/06/09 Relevance Score: 87%

Delayed release dexlansoprazole in the treatment of GERD and erosive esophagitis
Clinical and Experimental Gastroenterology, 11/17/09 Relevance Score: 80%

Mylan Receives FDA Approval for Generic Version of Prevacid Through its Subsidiary Matrix Laboratories
Mylan, 11/11/09 Relevance Score: 80%

Acute Kidney Injury in Patients with Inactive Cytochrome P450 Polymorphisms
Renal Failure, 10/30/09 Relevance Score: 80%

Safety profile of dexlansoprazole MR, a proton pump inhibitor with a novel dual delayed release formulation: global clinical trial experience
Alimentary Pharmacology and Therapeutics, 10/23/09 Relevance Score: 80%