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Severe burns may affect the pharmacokinetics of some drugs, resulting in the need for higher dosages
Drugs & Therapy Perspectives, 07/29/09

Major burn injuries prompt physiological changes that may affect the pharmacokinetic properties of some drugs. Fluid imbalances early in the post–burn period followed by a hypermetabolic phase contribute to changes in exposure, which may result in the need for higher dosages to achieve target plasma drug concentrations.

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An Umbrella Review: Corticosteroid Therapy for Adults with Acute Asthma
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U-500 Regular Insulin: Clinical Experience and Pharmacokinetics in Obese, Severely Insulin Resistant Type 2 Diabetic Patients
Diabetes Care, 11/16/09

The role of ceramide in major depressive disorder
European Archives of Psychiatry and Clinical Neuroscience, 11/12/09

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