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Cardiac surgery patients may have clinically relevant changes in the pharmacokinetics of frequently used drugs
Drugs & Therapy Perspectives, 07/29/09
Various pathophysiological conditions may significantly alter the pharmacokinetic behaviour of drugs in patients undergoing cardiac surgery. To avoid either overexposure and the consequent increased risk of toxicity, or underexposure and the consequent risk of therapeutic failure, the dosage regimens of certain agents in this patient population may need to be adjusted from those suggested for clinically stable patients.
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