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Kobalava ZD et al. – The study demonstrates the value of including the thiazide–like diuretic indapamide SR in a combined antihypertensive regimen to control BP in hypertensive patients with added cardiovascular risk factors whose hypertension is difficult to treat. Methodological limitations of this study are its open–label design and the possibility of a change in concomitant antihypertensive treatment during the study.

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