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Cytotoxicity of withanolides isolated from Acnistus arborescens
Fitoterapia, 07/28/09

Cordero CP et al. – Cytotoxic activity of these two compounds against human tumor cell lines HT–29, MCF–7, MKN–45, HEp–2, HeLa, U–937 and two human normal fibroblast cultures, Fib04 and Fib05, were assessed. Withanolide D presented in vitro cytotoxic activity against tumor cell lines at the low micromolar range and showed a slightly lower activity against Fib04, suggesting moderated selectivity among tumoral and normal cells. No cytotoxic effect was observed for 12 beta–acetoxy–4–deoxy–5,6–deoxy–delta 5–withanolide D.

Today in Chemotherapy/Oncology...keeping you current

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Comparative proteomic profiling identified sorcin being associated with gemcitabine resistance in non-small cell lung cancer
Medical Oncology, 12/17/09

A prospective phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer
Investigational New Drugs, 12/17/09

Phase I trial of motexafin gadolinium and doxorubicin in the treatment of advanced malignancies
Investigational New Drugs, 12/17/09

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Today in Complementary Medicine...keeping you current

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Hibiscus Sabdariffa L. Tea (Tisane) Lowers Blood Pressure in Prehypertensive and Mildly Hypertensive Adults
The Journal of Nutrition, 12/17/09

Clinical Effect of a Topical Herbal Ointment on Pain in Temporomandibular Disorders: A Randomized Placebo-Controlled Trial
Journal of Alternative and Complementary Medicine, 12/17/09

An Herbal Nasal Drop Enhanced Frontal and Anterior Cingulate Cortex Activity
Evidence-based Complementary and Alternative Medicine , 12/16/09

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