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The Acceptability, Safety, and Tolerability of Methadone/Naloxone in a 50: 1 Ratio
Experimental and Clinical Psychopharmacology, 07/24/09

Bell J et al. – Methadone–naloxone in a 50:1 ratio intramuscularly precipitated mild to moderate signs of opioid withdrawal in 4 out of 5 subjects whereas a 5th subject who did not experience withdrawal at a lower dose refused higher dose challenges. Withdrawal symptoms peaked 15 to 30 minutes postchallenge and returned to baseline levels at 60 minutes. Methadone–naloxone in 50:1 ratio has the pharmacological properties to be a useful combination product for treatment of heroin addiction with reduced risk of injection.

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