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See Latest Articles(A)DME of the Dopamine Agonist Rotigotine in Man — Administration by Intravenous Infusion or Transdermal Delivery
Drug Metabolism and Disposition, 07/20/09
Cawello W et al. – The major rotigotine biotransformation pathway was conjugation of the parent compound, mainly by sulfation; a second pathway was the formation of phase 1 metabolites with subsequent conjugation. Plasma concentration–time profiles of unchanged rotigotine during and after infusion and during and after patch administration were comparable.
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