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Selective antagonism of anticancer drugs for side-effect removal
Trends in Pharmacological Sciences, 07/15/09
Fernandez A et al. - The authors propose a mode of 'therapeutic editing' where one drug suppresses the side effect promoted by the primary drug as it impacts off-target cells. Editor and primary drug have overlapping therapeutic impact, and the editor suppresses the downstream propagation of toxicity-related signaling.
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