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See Latest ArticlesEffect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers
Journal of Clinical Pharmacy and Therapeutics, 07/10/09
Babalola CP et al. - The decreased plasma concentrations of the metabolite are presumably caused by metabolic inhibition of CYP3A4 by fluconazole. Although the therapeutic consequences of this interaction are not clear caution should be exercised when co-administering both drugs to avoid accumulation and subsequent cardiotoxic effects of halofantrine.
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