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See Latest ArticlesEffects of voriconazole on tacrolimus metabolism in a kidney transplant recipient
Journal of Clinical Pharmacy and Therapeutics, 07/10/09
Capone D et al. - The present drug–drug interaction can be attributed to a strong inhibitory effect on cytochrome P450-3A4 activity by voriconazole. When voriconazole and tacrolimus are coadministered, close monitoring of tacrolimus blood levels is recommended as the rule-of-thumb reduction of tacrolimus dose by one-third may not be satisfactory.
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