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See Latest ArticlesComparison of genetic polymorphisms of the NAT2 gene between Korean and four other ethnic groups
Journal of Clinical Pharmacy and Therapeutics, 07/06/09
Kang TS et al. - Ethnic differences in the NAT2 genotype frequencies may be one of the important factors explaining variability in cancer incidence and drug toxicity. This observations could be useful in assessing the susceptibility of different populations to cancer and contribute to better predictions of the pharmacokinetics and pharmacodynamics of drugs that are metabolized by NAT2, in different populations.
Jaesook Roh, 07/08/09
| We evaluated several genes encoding drug-metabolizing enzymes including NAT2, CYP2C19, CYP2D6, and three alcohol-metabolizing enzymes. Although there are much similarity between Korean and other Asians in genetic polymorphisms, we still found differences between them. Ethnic differences in genetic polymorphisms of tans of important genes need to be clarified of their important clinical meaning. It could be served as a clue for predetermine any susceptibility to specific medications or diseases in the near future. |
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