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Clinical Challenges in Addressing Resistance to Antimicrobial Drugs in the Twenty-First Century
Clinical Pharmacology & Therapeutics, 07/02/09

Septimus EJ et al. - Among the gram-positive pathogens, methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus species are the biggest threats. The situation is even more alarming with respect to gram-negative pathogens, especially because there are currently no late clinical trials involving new anti-infective drugs that are active against these pathogens.

Exclusive Author Commentary
EJ Septimus, 07/06/09

This article highlights a growing and seriuos challenge which shuold be included in any health care reform. To date, the current proposals on health care reform have failed to adequately address antimicrobial resistance or prevention of hospital infections. Just providing coverage without taking out the waste and harm in our system will not deliver the quality of care politicians always talk about. One of the greatest advances in public health in the last century has been vaccine-preventable diseases and the development of antibiotics to treat seriuos infections. Isn't it ironic that on both these fronts we are now going the wrong direction!

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