Pharmacy Medical News about COX-2 Selective Inhibitors; Cardiovascular Risk

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Potential Mechanisms of COX-2 Selective Inhibitors Affecting Cardiovascular Risk
Journal Of Cancer Pain & Symptom Palliation, 06/30/09

Smith HS - It appears that in COX-2 selective inhibitors may increase the risk of major adverse cardiovascular events. Various potential mechanisms are presented whereby COX-2 selective inhibitors may enhance the risk of cardiovascular events in certain patients. It is conceivable that different mechanisms may be involved in different circumstances and that multifactorial mechanisms may occasionally be operating in conjunction with one another.

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Selective COX-2 inhibitor versus nonselective COX-1 and COX-2 inhibitor in the prevention of heterotopic ossification after total hip arthroplasty: a meta-analysis of randomised trials
International Orthopaedics, 10/19/09 Relevance Score: 81%

Gastrointestinal Safety of Nonsteroidal Antiinflammatory Drugs and Selective Cyclooxygenase-2 Inhibitors in Patients on Warfarin
Annals of Pharmacotherapy, 10/13/09 Relevance Score: 68%

Targeting of HDAC8 and investigational inhibitors in neuroblastoma
Expert Opinion on Investigational Drugs, 10/12/09 Relevance Score: 68%

Proteasome Inhibitors in Cancer Therapy
Current Drug Targets, 10/23/09 Relevance Score: 67%

Combined Inhibition of Janus Kinase 1/2 for the Treatment of JAK2V617F-Driven Neoplasms: Selective Effects on Mutant Cells and Improvements in Measures of Disease Severity
Clinical Cancer Research, 11/09/09 Relevance Score: 66%