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Sliesoraitis S et al. - The authors present a case of methotrexate-induced Hodgkin disease in a 48-year-old man with a history of systemic lupus erythematosus (SLE). Discontinuation of methotrexate facilitated Hodgkin disease reversal.

Exclusive Author Commentary
Sarunas Sliesoraitis, 06/27/09

"Methotrexate-Induced Hodgkin Disease in a Patient With Systemic Lupus Erythematosus" is just a small report which I hope could lead to bigger future discoveries. Although so much has been achieved even in the last few years, there are several tumors waiting to be explored. EBV is one of the potential future targets for tumor treatment. If withdrawal of immune suppression leads to regression of tumor, then erradication or suppression of viral growth should potentially achieve more impressive results! Viral specific therapies rather than cell kill should lead to improved toxicity profile and improve ultimate survival. I do hope that you will enjoy our article. Thank you! Sarunas Sliesoraitis, DO, PharmD

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