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See Latest ArticlesAlpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3
Journal of Pharmacology and Experimental Therapeutics, 06/26/09
Musch MW et al. - Activation of intestinal epithelial a2AR significantly blocks the inhibition of apical Na+ transporters by cAMP- and Ca++-mediated pathways and also directly increases apical sodium/hydrogen exchange activities. By both blocking electrolyte secretion and promoting absorption, alpha2-agonists could be potent anti-diarrheal agents that could directly counteract the actions of toxigenic pathogens and other secretatogues causing secretory diarrhea.
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