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Greene J et al. - These studies show that VEGF is necessary for the behavioral effects of the SSRI fluoxetine, as well as norepinephrine selective reuptake inhibitor, and that these effects may be mediated by 5-HT1A receptors located on neurons and endothelial cells.


Exclusive Author Commentary
Dr RS Duman, 06/25/09

This paper extends previous work on the role of VEGF in the neurogenic and behavioral actions of antidepressant treatments. Studies are currently underway to determine the cellular mechanisms underlying the actions of VEGF, and association VEGF polymorphisms in mood disorder patients, work that could lead to novel therapeutic interventions.

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