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See Latest ArticlesPain Responder Analysis: Use of Area Under the Curve to Enhance Interpretation of Clinical Trial Results
Pain Practice, 06/23/09
Cappelleri JC et al. - Interpretation of results on patient-reported pain outcomes from clinical trials should be meaningful to patients and healthcare providers. This study applied an area-under-the-curve (AUC) analysis to responder profiles in a clinical trial of pregabalin for the treatment of fibromyalgia (FM)...Pain improvement was significantly better with pregabalin, with pregabalin responders improving by 8.4% (300 mg/day), 10.7% (450 mg/day), and 12.5% (600 mg/day) more than placebo responders. This novel approach demonstrates that responder profiles can provide an enhanced interpretation of pain outcomes for patient care and symptom management.
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