Pharmacy Medical News about Sleep-Disordered Breathing; Opioids

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Reversal of Sleep-Disordered Breathing with Opioid Withdrawal
Pain Practice, 06/23/09

Ramar et al. - The authors present a 30-year-old woman with excessive daytime sleepiness and sleep-disordered breathing for the past 4 years. Medical history was complicated by chronic osteomyelitis, periorbital abscess, and chronic facial pain requiring methadone for pain control for the last 4 years. In this case, adaptive servoventilator (ASV), though effective, was not tolerable due to chronic facial pain, and successful withdrawal of methadone at this pain rehabilitation center resolved the sleep-disordered breathing and improved daytime sleepiness. This is to the authors' knowledge the first case report of resolution of sleep-disordered breathing and improvement in daytime sleepiness after withdrawal of long-term opioid use.

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