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Identification and profiling of circulating metabolites of atazanavir, a human immunodeficiency virus protease inhibitor
Drug Metabolism and Disposition, 06/23/09
Heine RT et al. - All metabolites could be detected and possible other potential atazanavir keto-metabolites were found. Atazanavir metabolite levels were positively correlated with atazanavir levels, but inter-individual variability was high. The developed atazanavir metabolic screening method can now be used for further clinical pharmacological research with this antiretroviral agent.
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