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Bramlage P - The evidence indicates that angiotensin converting enzyme inhibitor (ACEi)/CCB combinations are more effective in selected high-risk patients with compelling indications for the use of CCBs than are ACEi/HCTZ combinations. Side effects offset these data, and compelling indications may have favored the outcomes. Comparisons in a more unselected patient population are needed to define the role of particular drug–drug combinations.

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