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The treatment and prevention of knee osteoarthritis: A tool for clinical decision-making
Expert Opinion in Pharmacotherapy, 06/22/09

Bliddal H et al. – Review focuses on increasing prevalence of degenerative diseases, related in part to steep increase in the prevalence of obesity. Need for more research into the associated osteoarthritis (OA) of weight-bearing joints is emphasized. Therapy may include dietary programs for weight loss as well as joint-saving exercises.

Methods

Aim was to review a hierarchy of interventions for OA in clinical practice, and compare it with the Strength of Recommendation (SOR) proposed by the Osteoarthritis Research Society International (OARSI)
Randomized controlled trials, published systematic reviews and meta-analyses were searched in databases

Results

Only a few preventive measures are available and they are uncertain
Basic therapy includes:
- Reduction in weight in the obese, and
- Exercises to keep in shape
  
  in accordance with the OARSI guidelines (OARSI) emphasizing the need for obese individuals with knee OA to loose weight
There are indications of an effect of some nutraceuticals, though further studies are needed for validation
Pharmacological treatment: paracetamol as primary prescription, which is a safe, albeit weak analgesic
Supplementary medications: prescribed according to level of pain and possible inflammation

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