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Terrell J et al. - Widespread administration of immunizations in the United States have helped eradicate such diseases as smallpox and poliomyelitis and can help prevent other serious illnesses and complications. Studies have shown that immunizations in adults aged 65 years and older reduce outpatient visits, hospitalizations, and deaths. Despite this, immunizations in adults continue to be underutilized. Each year, 50,000 U.S. adults die from vaccine-preventable diseases or their complications. Influenza kills approximately 36,000 people in the U.S. annually, with 90% of deaths occurring in those over the age of 65; pneumonia accounts for 11,000 to 14,000 deaths each year. Combined, pneumonia and influenza are the eighth leading cause of death in this country.

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