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See Latest ArticlesPresynaptic Regulation of Dopamine Transmission in Schizophrenia
Schizophrenia Bulletin, 06/17/09
Sulzer D et al. - A role for dopamine (DA) release in the hallucinations and other positive symptoms associated with schizophrenia has long been inferred from the antipsychotic response to D2 DA receptor antagonists and because the DA releaser amphetamine can be psychotogenic. Recent studies suggest that patients with schizophrenia, including those never exposed to antipsychotic drugs, maintain high presynaptic DA accumulation in the striatum.
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