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A randomized, comparative study evaluating the efficacy and tolerability of losartan-low dose chlorthalidone (6.25 mg) combination with losartan-hydrochlorothiazide (12.5 mg) combination in Indian patients with mild-to-moderate essential hypertension
Expert Opinion in Pharmacotherapy, 06/12/09
Pareek A et al. - The losartan/low-dose chlorthalidone combination is as effective as the widely used losartan/hydrochlorothiazide combination in lowering BP and is well tolerated, thus providing a useful therapeutic option for treating mild-to-moderate hypertension.
Anil Pareek, 06/16/09
| In this study chlorthalidone 6.25 mg in combination with losartan was compared with hydrochlorothiazide 12.5 mg in combination with losartan in the treatment of essential hypertension. Losartan - chlorthalidone combination was found to be as effective as losartan - hydrochlorothiazide in lowering BP. Thus again confirming that chlorthalidone is twice as potent as hydrochlorothiazide. |
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