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See Latest ArticlesHepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER)-stress induction, activation of PERK and GCN2 eIF2 alpha kinases and global translational shut-off
Molecular Pharmacology, 06/12/09
Acharya P et al. - These findings reveal that at high concentrations, MG132 is indeed cytotoxic and can suppress CYP3A synthesis, a result confirmed by confocal immunofluorescence analyses of MG132-treated hepatocytes.
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