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See Latest ArticlesSerine protease inhibitors as anti-hepatitis C virus agents
Expert Review of Anti-infective Therapy, 06/10/09
Reiser M et al. - In this review, the authors focus on the development and clinical application of serine protease inhibitors as anti-HCV agents. Although highly active in inducing a significant decline of serum HCV RNA, the rapid development of resistance must be counteracted in combination with other antiviral agents, currently pegIFN-alpha and ribavirin. Two serine protease inhibitors have reached clinical Phase III trials, increasing SVR rates and shortening treatment duration when combined with pegIFN and ribavirin. Trials of interferon-free targeted combination therapies are currently underway.
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