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Effects of levetiracetam and valproate on reproductive endocrine function studied in human ovarian follicular cells
Epilepsia, 06/08/09
Tauboll E et al. - LEV acts differently from VPA on reproductive endocrine function when studied in human ovarian follicular cells. LEV does not affect estradiol secretion, although both drugs affect CYP19 aromatase activity after gonadotropin stimulation. Both drugs act as apoptotic agents in ovarian cells. The proapoptotic effect of LEV was more pronounced than that of VPA.
Today in Basic Science...keeping you current
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The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways
Trends in Pharmacological Sciences, 12/15/09
UGT1A10: Activity against the tobacco-specific nitrosamine, NNAL, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility
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Glucuronidation of Psilocin and 4-Hydroxyindole by the Human UDP-glucuronosyltransferases
Drug Metabolism and Disposition, 12/14/09
Today in Neuro/Psych pharmacology...keeping you current
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Long-term levetiracetam treatment in patients with epilepsy: 3-year follow up
Acta Neurologica Scandinavica, 12/15/09
Milnacipran: Beyond a Role of Antidepressant
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