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See Latest ArticlesThe potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation
Journal of Pharmacology and Experimental Therapeutics, 06/12/09
Evenou JP et al. - AEB071 markedly inhibited LFA-1 mediated T cell adhesion at nanomolar concentrations. The mode of action of AEB071 is different from that of calcineurin inhibitors, and AEB071 and Cyclosporin A appear to have complementary effects on T cell signaling pathways.
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