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Results from the Clopidogrel Medco Outcomes study presented at the Society for Cardiovascular Angiography and Interventions (SCAI) 2009 Scientific Sessions showed that 1-year risk of cardiovascular events is increased more than 50% in patients taking a proton-pump inhibitor in combination with clopidogrel post–stent placement compared with patients not on PPI therapy poststenting; the risk appears to be a class effect.


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