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Shire plc, the global specialty biopharmaceutical company, announced results of a study showing that coadministration of the ADHD medication VYVANSE CII with the proton pump inhibitor Prilosec OTC 40 mg (20 mg X 2), did not alter the median time it took for maximum plasma concentration of d-amphetamine to be reached in the subjects evaluated. In the same study, coadministration of Prilosec OTC with ADDERALL XR resulted in a nearly 45 percent reduction in the median time to reach maximum plasma concentrations of amphetamine, the active medication. Other pharmacokinetic parameters of active medication were not altered for either VYVANSE or ADDERALL XR when coadministered with Prilosec OTC.
Today in Drug Interactions...keeping you current
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Drug-Drug Interaction Between Itraconazole and the Protease Inhibitor Lopinavir/Ritonavir
Annals of Pharmacotherapy, 11/25/09
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Today in Major Studies...keeping you current
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A Multicenter, Double-Blind, Randomized, Parallel Group Study Comparing Polyvinyl Chloride and Polyvinyl Chloride-Free Catheter Materials
The Journal of Urology, 11/24/09
Carboplatin-Pemetrexed Adjuvant Chemotherapy in Resected Non-small Cell Lung Cancer (NSCLC): A Phase II Study
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Cephalon, 11/06/09
Today in Over The Counter (OTC)...keeping you current
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Two cases of wheat-dependent anaphylaxis induced by aspirin administration but not by exercise
Clinical and Experimental Dermatology, 11/25/09
Clinical Features of Gastroduodenal Ulcer in Japanese Patients Taking Low-Dose Aspirin
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European Journal of Neurology, 11/23/09
Today in Pharmacokinetics...keeping you current
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Tacrolimus Population Pharmacokinetic-Pharmacogenetic Analysis and Bayesian Estimation in Renal Transplant Recipients
Clinical Pharmacokinetics, 11/24/09
Randomized Trial and Pharmacokinetic Study of Pegfilgrastim versus Filgrastim after Dose-Intensive Chemotherapy in Young Adults and Children with Sarcomas
Clinical Cancer Research, 11/20/09
Safety Profile, Pharmacokinetics, and Pharmacodynamics of Siplizumab, A Humanized Anti-CD2 Monoclonal Antibody, in Renal Allograft Recipients
Transplantation Proceedings, 11/20/09
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