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See Latest ArticlesLaser-evoked potentials as a tool for assessing the efficacy of antinociceptive drugs
European Journal of Pain, 05/27/09
Truini A et al. - LEPs are to date the reference standard technique for studying nociceptive pathway function in patients with neuropathic pain. To find out whether LEPs also provide a useful neurophysiological tool for assessing antinociceptive drug efficacy, in this double-blind placebo-controlled study the authors measured changes induced by the analgesic tramadol on LEPs in 12 healthy subjects. The authors found that tramadol decreased the amplitude of LEPs, whereas placebo left LEPs unchanged. The opioid antagonist naloxone partially reversed the tramadol-induced LEP amplitude decrease. The authors conclude that LEPs may be reliably used in clinical practice and research for assessing the efficacy of antinociceptive drugs.
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