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Fixed- or Controlled-Dose Mycophenolate Mofetil with Standard- or Reduced-Dose Calcineurin Inhibitors: The Opticept Trial
American Journal of Transplantation, 05/22/09
Gaston RS et al. - Of the 80% of subjects taking tacrolimus (Tac), those with higher MPA exposure had significantly less rejection and diarrhea correlated with Tac, but not with MPA levels. Thus, MMFCC with low-dose CNI resulted in outcomes not inferior to those with standard CNI exposure and MMFFD, indicating potential utility of MMFCC in CNI-sparing regimens.
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