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Gilead Sciences, Inc. announced results from ARIES-3, an open-label, single-arm, Phase III study evaluating the efficacy and safety of ambrisentan in patients with pulmonary hypertension, which showed a mean 21-meter improvement from baseline in six-minute walk distance at 24 weeks. Ambrisentan is approved under the tradename Letairis as a once-daily treatment for pulmonary arterial hypertension in patients with WHO functional class II or III symptoms to improve exercise capacity and delay clinical worsening. The ARIES-3 study included patients with PAH as well as patients with pulmonary hypertension due to other etiologies.


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