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See Latest ArticlesGlycerolysis of acyl glucuronides as an artifact of in vitro drug metabolism incubations
Drug Metabolism and Disposition, 05/14/09
Obach RS et al. - Other drugs that are converted to acyl glucuronides in vitro were also shown to form corresponding glycerol esters when incubated with human liver S-9 fraction and UDPGA. The potential formation of glycerol esters of carboxylic acid drugs undergoing acyl glucuronidation in vitro represents an experimental artifact to which drug metabolism scientists should be aware.
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