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Intrajejunal levodopa infusion in Parkinson's disease: A pilot multicenter study of effects on nonmotor symptoms and quality of life
Movement Disorders, 05/12/09

Honig H et al. – Results are the first findings that a levodopa-based continuous dopaminergic stimulation is beneficial for nonmotor symptoms (NMSs) and health-related quality of life in Parkinson's disease (PD) in addition to reduction of motor fluctuations and dyskinesias.

• Prospective open-label observational study of the effects of intrajejunal levodopa/carbidopa gel infusion on NMS in PD pts followed for 6 mo
• Standard assessments by Nonmotor Symptoms Scale (NMSS) and Unified Parkinson's Disease Rating Scale (UPDRS 3 motor and 4 complications)
• Quality of life (QoL) assessments by Parkinson's disease questionnaire (PDQ-8)
• Subjects: 22 advanced PD pts (mean age 58.6 yrs, disease duration 15.3 yrs)

• Statistically significant beneficial effect in 6 of 9 domains of NMSS: cardiovascular, sleep/fatigue, attention/memory, gastrointestinal, urinary, and miscellaneous (including pain and dribbling)
• Statistically significant benefits for total score of this scale (NMSST) paralleling improvement of motor symptoms (UPDRS 3 motor and 4 complications in best on state) and dyskinesias/motor fluctuations
• Significant improvements using Parkinson's disease sleep scale (PDSS) and PDQ-8 (QoL)
• Improvement in PDQ-8 scores correlated highly significantly with changes in NMSST
• Moderately strong correlation with UPDRS changes

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