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See Latest ArticlesGeneral practitioners' advice to use topical rather than oral ibuprofen resulted in equivalent effects on chronic knee pain
Evidence-Based Medicine, 05/08/09
Underwood M - The patient’s general practitioner prescribed or recommended preferential use of over-the-counter topical ibuprofen, applied according to manufacturer’s instructions, or oral ibuprofen, up to 1.2 g/day. Groups did not differ for change in WOMAC scores. Proportions of patients with 1 unplanned hospital admission were similar; no death or episode of gastric bleeding occurred in either group. Patients in the topical group had a lower rate of minor respiratory adverse effects , but groups did not differ for minor gastrointestinal (42% v 40%) or renovascular (16% v 15%) adverse effects. This study concludes that in older patients with chronic knee pain, general practitioners’ advice to use topical rather than oral ibuprofen resulted in equivalent effects on knee pain.
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