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See Latest ArticlesEffect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies
Clinical Pharmacology & Therapeutics, 05/07/09
Stoch SA et al. - These studies showed ODN to be well tolerated. Pharmacokinetic analysis revealed a long half-life consistent with once-weekly dosing. Pronounced reductions in C-terminal telopeptide of type I collagen and N-terminal telopeptide of type I collagen normalized to creatinine at trough were seen following weekly administration. Robust reductions in CTx and NTx/Cr were seen following daily administration. ODN exhibits robust and sustained suppression of bone resorption biomarkers at weekly doses >= 25 mg and daily doses >= 2.5 mg.
Today in Major Studies...keeping you current
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A prospective phase II study of cetuximab in combination with XELOX (capecitabine and oxaliplatin) in patients with metastatic and/or recurrent advanced gastric cancer
Investigational New Drugs, 12/18/09
Evaluation of Treatment Satisfaction in Children with Allergic Disease Treated with an Antihistamine: An International, Non-Interventional, Retrospective Study
Clinical Drug Investigation, 12/11/09
Sanofi Pasteur Global Dengue Vaccine Clinical Program Expanded in Latin America
Sanofi-aventis, 12/10/09
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Meta-analysis of the evidence for a partially hydrolyzed 100% whey formula for the prevention of allergic diseases
Current Medical Research and Opinion, 12/18/09
Vardenafil for the treatment of erectile dysfunction: an overview of the clinical evidence
Clinical Interventions in Aging, 12/18/09
Iron supplementation in the non-dialysis chronic kidney disease patient: oral or intravenous
Current Medical Research and Opinion, 12/18/09
Today in Pharmacokinetics...keeping you current
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Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action
Clinical Pharmacokinetics, 12/18/09
Semi-Mechanistic Population Pharmacokinetic Drug-Drug Interaction Modelling of a Long Half-Life Substrate and Itraconazole
Clinical Pharmacokinetics, 12/18/09
Population pharmacokinetics of posaconazole in neutropenic patients receiving chemotherapy for acute myelogenous leukemia or myelodysplastic syndrome
Current Medical Research and Opinion, 12/17/09
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