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Transdermal Patches and Burns
U.S. Pharmacist, 04/28/09

The total amount of drug absorbed and the resulting plasma drug concentrations from transdermal systems can increase during heat exposure. Duragesic labeling, for example, advises patients to avoid exposing the application site to direct external heat sources, such as heating pads, electric blankets, heat lamps, saunas, and hot tubs. Keep in mind that heat can increase skin permeability, vasodilation, and blood flow to the skin and may influence the delivery of other drugs from transdermal systems. Educate patients about this possibility, as increased drug absorption has compromised efficacy or led to drug toxicity.

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