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See Latest ArticlesResistance to Antimalarial Drugs: Molecular, Pharmacologic, and Clinical Considerations
Pediatric Research, 05/01/09
Travassos MA et al. - This review provides an update of the current understanding of the molecular basis for antimalarial drug resistance. Parasite intrinsic resistance is just one component that determines the in vivo efficacy of a drug. Human immune responses and pharmacologic properties play important roles in determining the clinical outcome of treatment. The emergence and spread of resistance also results from an interplay of these factors. Current efforts to characterize and deter resistance to new combination therapy are also discussed.
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