Pharmacy Medical News about hypoglycemic drugs; lactation

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Use of hypoglycemic drugs during lactation
Canadian Family Physician, 04/15/09

Glatstein MM et al. - The available data suggest that the levels of glyburide and glipizide in milk are negligible and would not be expected to cause adverse effects in breastfed infants; however, as data are based on a single study with a limited sample size, monitoring of the breastfed infant for signs of hypoglycemia is advisable during maternal therapy with any of these agents. Treatment with metformin during lactation is unlikely to lead to toxicity in the breastfed infant. Given the safety profile of metformin, as compared with sulfonylureas, it is advisable to consider metformin as first-line treatment during lactation if this drug is appropriate for the particular patient. Nevertheless, second-generation sulfonylureas are also likely to be safe during lactation. Other oral medications currently used for the treatment of type 2 diabetes, such as the thiazolidinediones and acarbose, have not been studied in the lactation period.

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