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See Latest ArticlesEarly Stopping Rules in Clinical Trials Based on Sequential Monitoring of Serious Adverse Events
Medical Decision Making, 04/20/09
Kramar A et al. - Several multistage or group sequential statistical methods have been developed for defining stopping rules in terms of efficacy in phase II and III clinical trials, but they rely on interim analyses after the inclusion of a fixed number of patients. These methods, however, need to be adapted for the evaluation of serious adverse events (SAEs), which can occur relatively early in the trial. A high frequency of their occurrence may require the trial to close early.
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