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Structural determinants of imidazoacridinones facilitating antitumor activity are crucial for substrate recognition by ABCG2
Molecular Pharmacology, 04/07/09
Bram EE et al. - Results establish that the IA determinants mediating cytotoxicity are precisely those that facilitate ABCG2-dependent drug efflux and IA resistance. The possible clinical implications for the future design of novel acridines that overcome ABCG2-dependent multidrug resistance are discussed.
Today in Cardiac/Hypertension...keeping you current
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Prasugrel for acute coronary syndromes: Faster, more potent, but higher bleeding risk
Cleveland Clinic Journal of Medicine, 12/04/09
Q: Is an ACE inhibitor plus an ARB more effective than either drug alone?
Cleveland Clinic Journal of Medicine, 12/04/09
Interferon-gamma (INF-gamma) release test can detect cutaneous adverse effects to statins
International Journal of Dermatology, 12/03/09
Today in Drug Resistance...keeping you current
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Characterization of Baseline Methicillin-Resistant Staphylococcus aureus Isolates Recovered from Phase IV Clinical Trial for Linezolid
Journal of Clinical Microbiology, 12/03/09
Two antimalaria drugs are tolerated regimens in regions with resistance
Formulary , 12/02/09
Imipenem Resistance in Pseudomonas aeruginosa: Emergence, Epidemiology, and Impact on Clinical and Economic Outcomes
Infection Control and Hospital Epidemiology, 12/02/09
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