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See Latest ArticlesLocalization of Multidrug Resistance-Associated Protein 2 (MRP2) in the Non-Pigmented Ciliary Epithelium of the Eye
Journal of Pharmacology and Experimental Therapeutics, 04/08/09
Pelis RM et al. - These data are consistent with MRP2-mediated transport activity in cultured NPE, and indeed, MRP2 mRNA and protein were detected in the cultured cells. Immunolocalization studies in native human and porcine eyes showed MRP2 protein at the apical interface of the NPE and pigmented cell layers. Close examination of MRP2 immunoreactivity supported the conclusion that MRP2 is localized in the apical membrane of the NPE. MRP2 at the apical membrane of NPE cells may be involved in protecting intraocular tissues from exposure to potentially harmful toxins.
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