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Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays
Advanced Drug Delivery Reviews, 02/06/09
Hegedus C et al. - When describing the most applicable assay systems, in each case authors present a short overview relevant to ABC multidrug transporters in general, and then authors concentrate on the tools applicable to analysis of substrate-drug interactions, the effects of potential activators and inhibitors, and the role of polymorphisms of the ABCG2 transporter. Throughout this chapter authors focus on recently developed assay systems, which may provide new possibilities for analyzing the pharmacological aspects of this medically important protein.
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