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See Latest ArticlesCyclooxygenase products and atherosclerosis
Drug Discovery Today: Therapeutic Strategies, 12/15/08
Linton MF et al. - Prostaglandins (PGs) and their specific receptors play critical roles in atherothrombosis. Produced from arachidonic acid via two cyclooxygenase (COX) isoforms, PGs mediate their actions via G-protein coupled receptors. Thromboxane (TX) A2 is a vasoconstrictor and platelet agonist, prostacyclin (PGI2) is a vasodilator that inhibits platelet function, and PGE2 modulates inflammation. The cardioprotective effects of aspirin are attributed to inhibition of COX-1 mediated platelet TX production.
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