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See Latest ArticlesProstate-specific antigen levels in relation to consumption of nonsteroidal anti-inflammatory drugs and acetaminophen
Cancer, 09/18/08
Singer EA et al. - In a study to determine the precise correlation between oral nonsteroidal anti-inflammatory drugs (NSAIDs) use, serum prostate-specific antigen (PSA), and prostate cancer risk, it was found that regular NSAID consumption may reduce serum PSA levels. Whether this is indicative of a protective effect on prostate cancer risk or masks possible prostate injury resulting in reduced detection of prostate cancer is unclear
Methods- PSA levels were determined in 1319 men aged >40 years in the 2001-2002 National Health and Nutrition Examination Survey
- Linear regressions were performed on log-transformed PSA levels to evaluate the relations between PSA and the use of NSAIDs and acetaminophen after adjusting for effects of age, race, educational level, smoking status, body mass index, coexisting inflammatory conditions, and heart disease
- NSAID and acetaminophen consumption displayed a negative association with PSA levels, namely, individuals who reported using NSAIDs (19.8%) or acetaminophen (1.3%) regularly had lower PSA levels than individuals who did not take these drugs, although the impact of acetaminophen was not statistically significant
- PSA levels among NSAID users were 0.9 times the levels among nondrug takers; PSA levels among acetaminophen users were 0.76 times the levels in nondrug takers
- Individuals who said they took both NSAIDs and acetaminophen regularly had higher PSA levels, although not statistically significantly so, than individuals who stated they did not take either of these drugs regularly
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