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Increased Active Metabolite Formation Explains the Greater Platelet Inhibition With Prasugrel Compared to High-dose Clopidogrel
Journal of Cardiovascular Pharmacology, 12/03/07
Farid, N., et al. - Prasugrel pharmacodynamics and pharmacokinetics after a 60-mg loading dose (LD) and daily 10-mg maintenance doses (MD) were compared in a 3-way crossover study to clopidogrel 600-mg/75-mg and 300-mg/75-mg LD/MD in 41 healthy, aspirin-free subjects. Each LD was followed by 7 days of daily MD and a 14-day washout period. Inhibition of platelet aggregation (IPA) was assessed by turbidometric aggregometry (20 and 5 [mu]M ADP)
Today in Cardiac/Hypertension...keeping you current
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Review: aspirin reduces vascular events but increases bleeding in primary and secondary prevention
Evidence-Based Medicine, 12/07/09
In patients with type 2 diabetes, perindopril-indapamide had similar relative reductions in mortality and cardiac events regardless of AF status
Evidence-Based Medicine, 12/07/09
Prospective, randomized, single-blind comparison of effects of 6 months of treatment with telmisartan versus enalapril on high-molecular-weight adiponectin concentrations in patients with coronary artery disease
Clinical Therapeutics, 12/07/09
Today in Dosing...keeping you current
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Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial
Amyotrophic Lateral Sclerosis, 12/07/09
Potential interactions between cilostazol and probucol: A two-part, single-dose, open-label study in healthy Korean male volunteers
Clinical Therapeutics, 12/07/09
Effects of food intake on the pharmacokinetics of diclofenac potassium soft gelatin capsules: A single-dose, randomized, two-way crossover study
Clinical Therapeutics, 12/07/09
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